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SML0059

Sigma-Aldrich

BLT-1

≥98% (HPLC)

Synonym(s):

2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53

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About This Item

Empirical Formula (Hill Notation):
C12H23N3S
CAS Number:
321673-30-7
Molecular Weight:
241.40
MDL number:
MFCD00571007
UNSPSC Code:
51111800
PubChem Substance ID:
329825125
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥13 mg/mL

storage temp.

2-8°C

SMILES string

CCCCCCC1CCC\C1=N/NC(N)=S

InChI

1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+

InChI key

OWGUSBISUVLUJF-SDNWHVSQSA-N

Application

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.
BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Biochem/physiol Actions

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes
Maddaloni E, et al.
Cardiovascular Diabetology, 16(1), 1-11 (2017)
Ivana Halova et al.
Frontiers in immunology, 3, 119-119 (2012-06-02)
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react
Ceren Emre et al.
Brain pathology (Zurich, Switzerland), 30(3), 614-640 (2020-01-09)
Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of the inflammatory stimuli. Acute inflammation
Fumiyuki Sasaki et al.
PloS one, 12(9), e0185133-e0185133 (2017-09-19)
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available. In this
Simin Zhao et al.
EBioMedicine, 44, 361-374 (2019-05-16)
Our preclinical data showed that the leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and leukotriene B4 receptor type 1 (BLT1) were also associated with CRC survival probability. Clinical samples were evaluated
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