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SML0443

Sigma-Aldrich

SU-5402

≥98% (HPLC), powder, FGFR inhibitor

Synonym(s):

3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908

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About This Item

Empirical Formula (Hill Notation):
C17H16N2O3
CAS Number:
215543-92-3
Molecular Weight:
296.32
MDL number:
MFCD08235144
UNSPSC Code:
51111800
PubChem Substance ID:
329824725
NACRES:
NA.77

product name

SU-5402, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

light yellow to dark orange

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O

InChI

1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

InChI key

JNDVEAXZWJIOKB-JYRVWZFOSA-N

Application

SU5402 has been used as a fibroblast growth factor receptor inhibitor:
  • in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
  • to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
  • to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
  • to study its effect on osteogenic markers.

Biochem/physiol Actions

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system
Cao F, et al.
Biochemical and Biophysical Research Communications, 491(3), 578-586 (2017)
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
Yamashita T, et al.
The Journal of Biological Chemistry, 277(31), 28265-28270 (2002)
BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification
Liu X, et al.
Biochemical and Biophysical Research Communications, 503, 930-937 (2018)
Fang Liang et al.
Scientific reports, 5, 14468-14468 (2015-10-09)
Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to
Carmen Andrikou et al.
Development (Cambridge, England), 148(10) (2021-05-18)
FGF signaling is involved in mesoderm induction in members of deuterostomes (e.g. tunicates, hemichordates), but not in flies and nematodes, in which it has a role in mesoderm patterning and migration. However, we need comparable studies in other protostome taxa
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