SML1466

ABH hydrochloride

≥98% (HPLC)

• Synonym(s): 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₄BNO₄ · HCl
• CAS Number: 194656-75-2
• Molecular Weight: 211.45
• MDL number: MFCD22887376
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825900
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +8 to +13°, c = 0.7 in H₂O
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• InChI key: XCUVEZUCSHVMRK-JEDNCBNOSA-N

Description

Biochem/physiol Actions

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable