Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

SRE0078

Sigma-Aldrich

Aprotinin

≥3 TIU/mg solid, lyophilized powder, ≥96% (HPLC)

Synonym(s):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
Molecular Weight:
6511.44
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

product name

Aprotinin from bovine lung, lyophilized powder, ≥3 TIU/mg solid

description

For research or further manufacturing use only. Not intended for direct use in humans or animals. Non-TSCA use only in US.

Quality Level

Assay

≥96% (HPLC)

form

lyophilized powder

specific activity

≥3 TIU/mg solid

mol wt

~6,500

shipped in

wet ice

storage temp.

2-8°C

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Unit Definition

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service