T3309

Transferrin human

≥98%

• Synonym(s): Siderophilin, partially saturated
• CAS Number: 11096-37-0
• EC Number: 234-318-8
• MDL number: MFCD00132442
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: human
• Quality Level: 200
• Assay: ≥98%
• form: powder
• Iron content: 300-600 ppm
• technique(s): cell culture | stem cell: suitable
• impurities: ≤1.0 EU/mg endotoxin
• UniProt accession no.: P02787
• storage temp.: 2-8°C
• Gene Information: human ... TF(7018)

Description

General description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Application

Transferrin has been used:

• in isolation of epidermal stem cells and cell expansion
• to study the effect of compound treatment on transferrin uptake
• for transferrin uptake and confocal imaging

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.

Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.

Analysis Note

Purity by agarose electrophoresis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3