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T8931

Sigma-Aldrich

Thyrotropic hormone from bovine pituitary

Synonym(s):

TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

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1 VIAL
$325.00
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$2,350.00

$325.00


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1 VIAL
$325.00
10 VIALS
$2,350.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32

$325.00


Availability
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biological source

bovine pituitary glands

form

powder

packaging

vial of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

cow ... TSHB(281552)
human ... TSHR(7253)

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General description

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland.[2] It circulates in free form and possess a short plasma half-life.[3]

Application

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.[4]
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.[5]
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.[6]
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.[7]

Biochem/physiol Actions

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function.[8] In children, TSH plays a vital role in normal cognition and neurodevelopment.[9] Circulating TSH is capable of binding to cell surface receptors in the thyroid gland.[2] This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer.[10] It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.[11]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Quality

Contains phosphate buffer salts

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Dong Lin et al.
Journal of cellular physiology, 237(1), 868-880 (2021-08-27)
Diabetic retinopathy (DR) is a common complication of diabetes mellitus. High glucose-induced mitochondrial apoptosis is involved in the loss of retinal pericytes (PCs), which is considered to be a predominant pathologic change of diabetic retinopathy (DR). A high thyroid stimulating
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
Lal G, et al.
Cancer, 107(12), 2752-2759 (2006)
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)

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