P6628

Pilocarpine nitrate salt

≥98% (HPLC), muscarinic acetylcholine receptor agonist, powder

• Fórmula empírica (notación de Hill): C₁₁H₁₆N₂O₂ · HNO₃
• Número CAS: 148-72-1
• Peso molecular: 271.27
• NACRES: NA.77
• PubChem Substance ID: 57654548
• UNSPSC Code: 12352200
• EC Number: 205-723-7
• MDL number: MFCD00078497
• Beilstein/REAXYS Number: 4171406
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Pilocarpine nitrate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]25/D +83°, c = 10 in H₂O(lit.)
• color: white
• solubility: H₂O: 100 mg/mL
• SMILES string: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• InChI key: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Descripción

Application

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Nonselective muscarinic acetylcholine receptor agonist.

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Información de seguridad

• pictograms: GHS03,GHS06
• signalword: Danger
• hcodes: H272,H302,H330
• pcodes: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Clase de almacenamiento: 5.1B - Oxidizing hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges