SML0517

Amlexanox

≥98% (HPLC)

• Sinónimos: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, AA 673, Amoxanox, CHX 3673
• Fórmula empírica (notación de Hill): C₁₆H₁₄N₂O₄
• Número CAS: 68302-57-8
• Peso molecular: 298.29
• NACRES: NA.77
• PubChem Substance ID: 329825526
• UNSPSC Code: 12352200
• MDL number: MFCD00864790
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL at warmed, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O
• InChI: 1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
• InChI key: SGRYPYWGNKJSDL-UHFFFAOYSA-N
• Gene Information: human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Descripción

General description

Amlexanox is an anti-allergic drug with anti-inflammatory properties.

Biochem/physiol Actions

Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.

Amlexanox is an anti-allergy, anti-ulcer drug; S100A13 inhibitor.

Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable