Z0878

Zaprinast

cGMP-specific phosphodiesterases V and VI inhibitor, solid

• Sinónimos: 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• Fórmula empírica (notación de Hill): C₁₃H₁₃N₅O₂
• Número CAS: 37762-06-4
• Peso molecular: 271.27
• NACRES: NA.77
• PubChem Substance ID: 24278072
• UNSPSC Code: 12352202
• EC Number: 253-655-1
• MDL number: MFCD00214073
• Form: solid

Propiedades

• Nombre del producto: Zaprinast, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H₂O: insoluble
• SMILES string: CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N
• Gene Information: human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

Descripción

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves