202398

Poly(ethylene glycol)

average M_n 400, hydroxyl

• Synonyma: Polyethylene glycol, PEG
• Lineární vzorec: H(OCH₂CH₂)_nOH
• Číslo CAS: 25322-68-3
• UNSPSC Code: 12352104
• PubChem Substance ID: 24852060
• NACRES: NA.23
• MDL number: MFCD00081839
• eCl@ss: 32150312

Vlastnosti

• Název produktu: Poly(ethylene glycol), average M_n 400
• form: viscous liquid
• Quality Segment: 200
• mol wt: M_n 380-420, average M_n 400
• sustainability: Sustainability features
• refractive index: n20/D 1.466
• pH: 4.5-7.5
• viscosity: 7.3 cSt(210 °F)(lit.)
• mp: 4-8 °C (lit.)
• density: 1.128 g/mL
• Ω-end: hydroxyl
• α-end: hydroxyl
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Popis

General description

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are non-toxic, FDA-approved, generally non-immunogenic, and frequently used in many biomedical applications including bioconjugation, drug delivery, surface functionalization, and tissue engineering. In drug delivery, PEGs can be used as linkers for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery.

Application

Poly(ethylene glycol) (PEG) has been used as a coating agent for the synthesis and in vitro safety assessment of magnetic bacterial cellulose (MBC) pellicles, performed on porcine aortic smooth muscle cells (PAOSMC). PEG provides a compatible surface for cell culture, since uncoated iron oxide NPs are considered cytotoxic to cells. It has also been used as a plasticizer in investigating the effectiveness of polyvinylpyrrolidone microneedles for transdermal delivery of functional collagen using porcine skin, adult human skin analog and human foreskin. Microneedles obtained, were reportedly characterized by various analytical and bio-analytical techniques.

Used in conjunction with carbon black to form a conductive composite. Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.

Solvent for greener fluorination of acetoacetamides with Selectfluor^®.

Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

Legal Information

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Skladovací třída: 10 - Combustible liquids
• WGK: WGK 1
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves