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About This Item
Linear Formula:
ClC6H4COC2H5
CAS Number:
Molecular Weight:
168.62
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
98%
form
solid
bp
124 °C/14 mmHg (lit.)
mp
45-47 °C (lit.)
SMILES string
CCC(=O)c1cccc(Cl)c1
InChI
1S/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3
InChI key
PQWGFUFROKIJBO-UHFFFAOYSA-N
Related Categories
General description
Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.
Application
3′-Chloropropiophenone can be used as a reactant to synthesize:
- (S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
- 1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
- (S)-Dapoxetine, a selective serotonin reuptake inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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[reaction: see text] The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.
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