404888

1-Methyl-2-phenylindole

99%

• Synonym(s): NSC 63793
• Empirical Formula (Hill Notation): C₁₅H₁₃N
• CAS Number: 3558-24-5
• Molecular Weight: 207.27
• EC Number: 222-618-1
• MDL number: MFCD00022892
• UNSPSC Code: 12352100
• PubChem Substance ID: 24865277
• NACRES: NA.22

Properties

• Assay: 99%
• mp: 98-100 °C (lit.)
• SMILES string: Cn1c(cc2ccccc12)-c3ccccc3
• InChI: 1S/C15H13N/c1-16-14-10-6-5-9-13(14)11-15(16)12-7-3-2-4-8-12/h2-11H,1H3
• InChI key: SFWZZSXCWQTORH-UHFFFAOYSA-N

Description

General description

Reaction of 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO₂-CH₃COOH) in benzene has been studied. 1-Methyl-2-phenylindole is reported to react with malondialdehyde (MDA) and 4-hydroxyalkenals to afford a stable chromophore with intense maximal absorbance at 586nm.

Application

1-Methyl-2-phenylindole may be used in the following studies:

• The estimation of lipid peroxidation in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg.
• As chromogenic agent for the determination of estimation of malondialdehyde (MDA) production.
• Colorimetric assay of lipid peroxidation.
• Synthesis of 1-methyl-2-phenyl-3-(1,3,4-thiadiazol-2-yldiazenyl)-1H-indole.
• Synthesis of 3-(5-ethyl-1,3,4-thiadiazol-2-yldiazenyl)-1-methyl-2-phenyl-1H-indole.

Reactant for preparation of:

• Cyano indoles
• Difluorohydroxy indoles

Reactant for:

• Carboxylation of indoles
• Allylation of indoles
• Formylation of indoles
• Nitrosylation of indoles

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable