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540242

Sigma-Aldrich

(R)-(−)-1,2-Propanediol

96%

Synonym(s):

(R)-(−)-Propylene glycerol, (R)-(−)-Propylene glycol

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About This Item

Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
4254-14-2
Molecular Weight:
76.09
Beilstein:
1718872
MDL number:
MFCD00066248
UNSPSC Code:
12352001
PubChem Substance ID:
24878449
NACRES:
NA.22

Assay

96%

optical activity

[α]20/D −16.5°, neat

optical purity

ee: 98% (GLC)

refractive index

n20/D 1.434 (lit.)

bp

186-188 °C/765 mmHg (lit.)

density

1.04 g/mL at 25 °C (lit.)

SMILES string

C[C@@H](O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1

InChI key

DNIAPMSPPWPWGF-GSVOUGTGSA-N

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Other Notes

(R)-(-)-1,2-Propanediol undergoes metabolization in the bovine rumen fluid by the rumen microbiota with the emission of sulfur-containing gases.

Legal Information

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

217.4 °F - closed cup

Flash Point(C)

103 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yang Zhao et al.
Nature communications, 8, 14180-14180 (2017-01-26)
Many naturally occurring biomolecules, such as amino acids, sugars and nucleotides, are inherently chiral. Enantiomers, a pair of chiral isomers with opposite handedness, often exhibit similar physical and chemical properties due to their identical functional groups and composition, yet show
Ruminal fermentation of propylene glycol and glycerol.
Trabue S, et al.
Journal of Agricultural and Food Chemistry, 55(17), 7043-7051 (2007)
A A Melo et al.
The Journal of laryngology and otology, 127(4), 359-363 (2013-02-15)
To determine whether the administration of mitomycin C prevents propylene glycol exposure from inducing middle-ear cholesteatoma and otitis media, in a rat model. Twenty-four Wistar rats underwent intratympanic injections on days 1, 8 and 15, via the tympanic membrane pars
Kenneth B Sloan et al.
Journal of cosmetic science, 64(3), 181-192 (2013-06-12)
It would be useful to develop a surrogate for animal skin, which could be use to predict flux through human skin. The fluxes (and physicochemical properties) of sunscreens and other compounds from propylene glycol (PG):water (AQ), 30:70, through human skin
Carla Caddeo et al.
International journal of pharmaceutics, 443(1-2), 128-136 (2013-01-10)
Diclofenac-loaded phospholipid vesicles, namely conventional liposomes, ethosomes and PEVs (penetration enhancer-containing vesicles) were developed and their efficacy in TPA (phorbol ester) induced skin inflammation was examined. Vesicles were made from a cheap and unpurified mixture of phospholipids and diclofenac sodium;
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