790427C

06:0 PC-d22

Avanti Research^™ - A Croda Brand 790427C

• Synonym(s): 1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine
• Empirical Formula (Hill Notation): C₂₀H₁₈NO₈PD₂₂
• CAS Number: 328946-18-5
• Molecular Weight: 475.64
• UNSPSC Code: 12352211
• NACRES: NA.12

Properties

• Assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (790427C-10mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 790427C
• concentration: 10 mg/mL (790427C-10mg)
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

Phosphatidylcholine is a zwitterionic glycerophospholipid, containing choline. It consists of a head and two tails. Head group contains choline and phosphate. Head is polar and water soluble. The tail group contains two fatty acyl chains esterified with glycerol. Tail group is non-polar and water-insoluble. Phosphatidylcholine is synthesized in the liver by phosphatidylethanolamine methyltransferase (PEMT) pathway. It is also synthesized by the Kennedy pathway and the Lands cycle.

Application

06:0 PC-d22 (1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine) has been used:

• as bicelles for lipid in HN-HN nuclear overhauser enhancement (NOE) detection
• as an internal standard in residual algal suspension for liquid chromatography-mass spectrometry analysis (LC-MS/MS)
• to produce bicelles to investigate C-peptide and membrane interaction by diffusion nuclear magnetic resonance (NMR) and 2D total correlation spectroscopy (TOCSY)

Biochem/physiol Actions

Phosphatidylcholine (PC) is a major component of the membrane bilayer. It is involved in the synthesis of signaling molecules. PC is the precursor for the synthesis of sphingomyelin and phosphatidylserine.

Packaging

5 mL Clear Glass Sealed Ampule (790427C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P260 - P280 - P301 + P312 + P330 - P304 + P340 + P311 - P305 + P351 + P338 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system
• WGK: WGK 3