810258E
Avanti
C11 TopFluor™ GM3
Avanti Research™ - A Croda Brand 810258E, ethanol solution
Synonym(s):
C11 TopFluor GM3 Ganglioside (ammonium salt)
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About This Item
Empirical Formula (Hill Notation):
C65H110BF2N5O21
CAS Number:
Molecular Weight:
1346.40
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
Assay
>99% (TLC)
form
ethanol solution
packaging
pkg of 1 × 1 mL (810258E-100ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810258E
concentration
0.1 mg/mL (810258E-100ug)
shipped in
dry ice
storage temp.
−20°C
General description
C11 TopFluor™ GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).
Application
C11 TopFluor™ GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.
Biochem/physiol Actions
Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.
Packaging
5 mL Amber Glass Screw Cap Vial (810258E-100ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
55.4 °F - closed cup
Flash Point(C)
13.0 °C - closed cup
Certificates of Analysis (COA)
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Christopher Lipina et al.
FEBS letters, 589(21), 3221-3227 (2015-10-06)
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the ganglioside GM3 has been linked to pathophysiological changes associated
Seiichi Tagami et al.
The Journal of biological chemistry, 277(5), 3085-3092 (2001-11-15)
Gangliosides are known as modulators of transmembrane signaling by regulating various receptor functions. We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase
Anshuman Das et al.
Nature microbiology, 5(9), 1069-1078 (2020-05-27)
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is
Jason G Kay et al.
Molecular biology of the cell, 23(11), 2198-2212 (2012-04-13)
Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and blood clotting using annexin V. However, because annexins are impermeant and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use. Thus
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