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Key Documents

07-402

Sigma-Aldrich

Anti-p70 S6 Kinase Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_003161

UniProt accession no.

P23443

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... RPS6KB1(6198)

Specificity

p70 S6 kinase

Immunogen

peptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine

Application

Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Quality

routinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells

Target description

64 kDa

Linkage

Replaces: 04-391

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
Baxter, R M, et al.
European Journal of Biochemistry, 234, 84-91 (1995)
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
Reinhard, C, et al.
Proceedings of the National Academy of Sciences of the USA, 89, 4052-4056 (1992)
Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.
Ballou, L M, et al.
The Journal of Biological Chemistry, 263, 1188-1194 (1988)
Zhiguang Xiao et al.
Oncotarget, 5(24), 12877-12890 (2014-11-07)
The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After
Jason P Chua et al.
Human molecular genetics, 23(5), 1376-1386 (2013-10-24)
Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen receptor (AR) gene. SBMA demonstrates androgen-dependent toxicity due to unfolding and aggregation of

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