S7507

Sulfamethoxazole

• Synonym(s): 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N¹-(5-Methylisoxazol-3-yl)sulfanilamide
• Empirical Formula (Hill Notation): C₁₀H₁₁N₃O₃S
• CAS Number: 723-46-6
• Molecular Weight: 253.28
• Beilstein: 6732984
• EC Number: 211-963-3
• MDL number: MFCD00010546
• UNSPSC Code: 41116107
• PubChem Substance ID: 329824585
• NACRES: NA.24

Properties

• Quality Level: 100
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• storage temp.: 2-8°C
• SMILES string: Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
• InChI: 1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
• InChI key: JLKIGFTWXXRPMT-UHFFFAOYSA-N

Description

General description

Sulfamethoxazole is a bacteriostatic antibiotic, belonging to the class of sulfonamides. It is widely used in the treatment of pneumocystis, coccidiosis, gastroenteritis, diarrhea, respiratory diseases such as pneumonia, etc.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Sulfamethoxazole is used as an analytical reference standard for the quantification of the analyte in milk samples using analytical and microbiological assay technique.

Biochem/physiol Actions

Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Safety Information

• Pictograms: GHS08,GHS09
• Signal Word: Warning
• Hazard Statements: H361fd,H411
• Precautionary Statements: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves