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T4562

Sigma-Aldrich

Thiamine hydrochloride

meets USP testing specifications

Synonym(s):

Aneurine hydrochloride, Vitamin B1 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
67-03-8
Molecular Weight:
337.27
Beilstein:
3851771
EC Number:
200-641-8
MDL number:
MFCD00012780
UNSPSC Code:
12352116
eCl@ss:
34058006
PubChem Substance ID:
24900215
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

98.0-102.0%

form

solid

mp

250 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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Application

Required to support energy metabolism and amino acid synthesis in cultured cells. Present in many classical and serum-free formulations.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000402700
0000402701
0000353785
0000353786
0000369760

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Joseph E Kerschner et al.
Archives of otolaryngology--head & neck surgery, 135(1), 33-39 (2009-01-21)
To investigate genetic differences in middle ear mucosa (MEM) with nontypeable Haemophilus influenzae (NTHi) infection. Genetic upregulation and downregulation occurs in MEM during otitis media (OM) pathogenesis. A comprehensive assessment of these genetic differences using the techniques of complementary DNA
Samir Ahmed El-Shazly et al.
International journal of immunopathology and pharmacology, 28(2), 227-239 (2015-03-31)
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to abnormalities in either insulin secretion or action. A range of vanadium complexes have been synthesized and demonstrated to be effective in lowering hyperglycemia. Thiamine administration was also
Ashish K Singh et al.
Alcoholism, clinical and experimental research, 38(7), 2127-2137 (2014-06-17)
Chronic ethanol (EtOH) consumption is associated with oxidative tissue damage, decrease in antioxidant enzyme activities, and increase in hepatic and plasma lipids. This study investigates the effect of modified probiotic Escherichia coli Nissle 1917 (EcN) secreting pyrroloquinoline quinone (PQQ) against
Kris Niño G Valdehuesa et al.
Bioprocess and biosystems engineering, 38(9), 1761-1772 (2015-06-07)
Biosynthetic pathways for the production of biofuels often rely on inherent aldehyde reductases (ALRs) of the microbial host. These native ALRs play vital roles in the success of the microbial production of 1,3-propanediol, 1,4-butanediol, and isobutanol. In the present study
Kangming Tian et al.
Biotechnology and bioengineering, 113(1), 182-188 (2015-07-15)
Efficient production of D-lactate by engineered Escherichia coli entails balancing cell growth and product synthesis. To develop a metabolic switch to implement a desirable transition from cell growth to product fermentation, a thiamine auxotroph B0013-080A was constructed in a highly
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Articles

Thiamine in Cell Culture

Explore thiamine's impact on serum-free cell culture systems for biomanufacturing monoclonal antibodies.

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