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156R-9

Sigma-Aldrich

CD56 (MRQ-42) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-42, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (156R-94)
vial of 0.5 mL concentrate (156R-95)
bottle of 1.0 mL predilute (156R-97)
vial of 1.0 mL concentrate (156R-96)
bottle of 7.0 mL predilute (156R-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... NCAM1(4684)

General description

CD56, also known as a neural cell adhesion molecule (NCAM), is a calcium-independenthomophilic binding protein that belongs to a group of cell adhesion molecules includingcadherins, selectins, and integrins. CD56 is involved in cell-cell adhesion of neural cellsduring embryogenesis and is expressed in most neuroectodermally derived tissues. Innormal tissue, anti-CD56 labels neurons, glia, Schwann cells, NK (natural killer) cells, and asubset of T-cells. CD56 expression can be seen in most NK cell neoplasms,4 and is frequentlyused to identify neoplasms with neuroendocrine differentiation.

Quality


IVD
IVD
IVD
RUO

Linkage

CD56 Positive Control Slides, Product No. 156S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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R Gerardy-Schahn et al.
International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 38-42 (1994-01-01)
Monoclonal antibodies (MAbs) ranked together as small-cell-lung-cancer (SCLC) Cluster I MAbs are directed against the neural cell adhesion molecule NCAM (CD 56) and have been shown to be useful reagents in SCLC diagnosis and therapy. We analyzed the epitopes recognized
R Michalides et al.
International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 34-37 (1994-01-01)
The presence of the neural cell adhesion molecule, NCAM, is indicative for a poor prognosis in lung-cancer patients. Using MAb 735, we have investigated the expression of polysialic acid, PSA, on NCAM in a spectrum of neuro-endocrine lung tumors, ranging
Scott A Ely et al.
The American journal of pathology, 160(4), 1293-1299 (2002-04-12)
Unlike monoclonal gammopathy of undetermined significance (MGUS) or non-Hodgkin's lymphomas (NHLs) with plasmacytoid differentiation, multiple myeloma (MM) is commonly associated with lytic bone lesions. Although the mechanisms of increased osteoclast activity are partially understood, comparatively little is known about the
Jianguo Tao et al.
The American journal of surgical pathology, 26(1), 111-118 (2002-01-05)
We report an unusual case of aggressive natural killer (NK)-like cytotoxic T-cell lymphoma in a previously healthy immunocompetent West African male. He presented with a fever of unknown origin, subsequently developed erythematous skin nodules, generalized lymphadenopathy, and hepatosplenomegaly, and then
O Kaufmann et al.
Human pathology, 28(12), 1373-1378 (1998-01-07)
CD56 is immunohistochemically detectable in virtually all small cell carcinomas on frozen sections. The authors retrospectively tested the usefulness of the monoclonal antibody 123C3 against CD56 to differentiate pulmonary and extrapulmonary small cell carcinomas from nonneuroendocrine non-small cell carcinomas by
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