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B5057

Sigma-Aldrich

7-Benzyloxy-4-trifluoromethylcoumarin

≥99% (HPLC), solid

Synonym(s):

7-BFC

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About This Item

Empirical Formula (Hill Notation):
C17H11F3O3
Molecular Weight:
320.26
MDL number:
MFCD01564466
UNSPSC Code:
12161501
PubChem Substance ID:
24891807
NACRES:
NA.47

product name

7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid

Quality Level

100

Assay

≥99% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12

InChI

1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2

InChI key

WVKLERKKJXUPIK-UHFFFAOYSA-N

Gene Information

rat ... Maoa(29253) , Maob(25750)

Application

7-Benzyloxy-4-trifluoromethylcoumarin has been used:

  • in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
  • in O-dealkylation reaction to determine the activity of CYP3A
  • to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)

Biochem/physiol Actions

Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.

Legal Information

Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Manami Nishiwaki et al.
Scientific reports, 10(1), 17503-17503 (2020-10-17)
Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from
Jiannan Ding et al.
Chemosphere, 148, 21-31 (2016-01-23)
The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU
Vamshi K Manda et al.
Phytotherapy research : PTR, 31(12), 1935-1945 (2017-10-27)
Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly.
Viktoriia Burkina et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-14)
Water from wastewater treatment plants contains concentrations of pharmaceutically active compounds as high as micrograms per liter, which can adversely affect fish health and behavior, and contaminate the food chain. Here, we tested the ability of the common carp hepatic
Risto O Juvonen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(9), 1015-1024 (2018-10-03)
Cytochrome P450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pathways. In this study, 10 novel profluorescent
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