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C8890

Sigma-Aldrich

4-Chloro-1-naphthol

horseradish peroxidase substrate, fluorogenic, ≥98% (GC), crystalline

Synonym(s):

4-chloronaphthalen-1-ol

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About This Item

Linear Formula:
ClC10H6OH
CAS Number:
604-44-4
Molecular Weight:
178.61
Beilstein:
509750
EC Number:
210-068-5
MDL number:
MFCD00003974
UNSPSC Code:
12352204
PubChem Substance ID:
57654054
NACRES:
NA.83

product name

4-Chloro-1-naphthol, crystalline

Assay

≥98% (GC)

form

crystalline

mp

118-121 °C (lit.)

solubility

acetone: 50 mg/mL, clear, colorless to very faintly brown

storage temp.

−20°C

SMILES string

Oc1ccc(Cl)c2ccccc12

InChI

1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H

InChI key

LVSPDZAGCBEQAV-UHFFFAOYSA-N

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Application

4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.

Biochem/physiol Actions

4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.

Substrates

Chromogenic peroxidase substrate useful in enzyme-linked detection procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation
JIMENEZ JJ, et al.
Journal of Thrombosis and Haemostasis, 3(6), 1301-1308 (2005)
Limited proteolysis of fibrinogen by fibrinogenase from Echis multisquamatis venom
Chernyshenko VO
The Protein Journal, 34(2), 130-134 (2015)
J M Elias
American journal of clinical pathology, 73(6), 797-799 (1980-06-01)
The substitution of 4-chloro-1-naphthol for benzidine-containing compounds used in the myeloperoxidase stain for distinguishing granulocytes from lymphoid blood elements is described. 4-Chloro-1-naphthol is an acceptable substitute for benzidine compounds, which are considered to be carcinogenic. The feasibility of using this
Elodie Fortin et al.
The Analyst, 131(2), 186-193 (2006-01-28)
We illustrate in this paper the successful combination of the direct and feedback mode of scanning electrochemical microscopy (SECM) for the writing of oligonucleotide patterns on thin gold films alongside the imaging of DNA hybridization. The patterning process was achieved
Shinya Nakashima et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(2), 588-597 (2011-01-06)
The hybrid ganglioside X1, which was identified in the bovine brain, was synthesized for the first time. Ganglioside X1 is believed to be involved in the development of amyotrophic lateral sclerosis-like disorders in patients with neurological disorders after treatment with
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