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D8008

Sigma-Aldrich

7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid

≥95%

Synonym(s):

DEDA

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About This Item

Empirical Formula (Hill Notation):
C22H40O2
CAS Number:
89560-01-0
Molecular Weight:
336.55
MDL number:
MFCD00133010
UNSPSC Code:
12352202
PubChem Substance ID:
24278388

biological source

synthetic (organic)

Assay

≥95%

form

liquid

storage temp.

−20°C

SMILES string

CCCCCCCCCCC\C=C/C(C)(C)\C=C/CCCC(O)=O

InChI

1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-

InChI key

AGKRHAILCPYNFH-DUQSFWPASA-N

Gene Information

human ... ADORA2A(135) , ADORA2B(136)

Biochem/physiol Actions

Inhibitor of phospholipase A2 and lipoxygenase. Inhibits endogenous synthesis of leukotrienes.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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S Giri et al.
Journal of lipid research, 47(7), 1478-1492 (2006-04-29)
Globoid cell leukodystrophy (Krabbe disease) is an inherited neurological disorder caused by the pathogenomic accumulation of psychosine (galactosylsphingosine), a substrate for the deficient enzyme galactocerebroside beta-galactosidase. This study underscores the mechanism of action of psychosine in the regulation of oligodendrocyte
Jannike M Andersen et al.
Neurochemical research, 28(2), 319-326 (2003-03-01)
In this paper we show that exposure of a rat brain synaptosome fraction to the amyloid beta peptide fragment betaA(25-35), but not the inverted peptide betaA(35-25), stimulated production of reactive oxygen species (ROS) in a concentration- and time-dependent manner. The
R T Worrell et al.
American journal of physiology. Cell physiology, 281(1), C147-C156 (2001-06-13)
Activity of the epithelial Na+ channel (ENaC) is the limiting step for discretionary Na+ reabsorption in the cortical collecting duct. Xenopus laevis kidney A6 cells were used to investigate the effects of cytosolic phospholipase A2 (cPLA2) activity on Na+ transport.
M D Lister et al.
The Journal of biological chemistry, 264(15), 8520-8528 (1989-05-25)
In order to ascertain the role of phospholipase A2 (PLA2) in the release of arachidonic acid for eicosanoid biosynthesis, we have characterized a Ca2+-dependent PLA2 from P388D1 cells, evaluated inhibitors of its activity, and correlated the effects of these inhibitors
Thomas L Williams et al.
Langmuir : the ACS journal of surfaces and colloids, 22(15), 6473-6476 (2006-07-13)
This letter describes a new method for studying the interaction of the membrane-lysing enzyme phospholipase A(2) (PLA(2)) with phospholipid bilayers by simultaneous measurements of enzyme binding and vesicle lysis using surface plasmon resonance (SPR) and permeabilization using surface plasmon field-enhanced
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