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E0251

Sigma-Aldrich

Estrone 3-sulfate sodium salt

contains ~35% Tris as stabilizer

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Linear Formula:
C18H21O5SNa
CAS Number:
438-67-5
Molecular Weight:
372.41
MDL number:
MFCD00070035
UNSPSC Code:
12352202
PubChem Substance ID:
24894364
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

Assay

≥98% (TLC)

form

powder

contains

~35% Tris as stabilizer

technique(s)

inhibition assay: suitable

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1

InChI key

GQZNDBBLTDOIBE-DLEHHZMWSA-N

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Package size based on steroid content

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Takashi Nozawa et al.
Pharmaceutical research, 22(10), 1634-1641 (2005-09-24)
The aim of the study is to suppress the progress of estrogen-dependent breast cancer by inhibiting the membrane transporter, which mediates the internalization of estrone-3-sulfate as estrogen precursor in the cancer cells. The uptake of estrone-3-sulfate by estrogen-dependent breast cancer
Emre Karakus et al.
Frontiers in pharmacology, 9, 941-941 (2018-09-07)
Estrogens play a pivotal role in the development and proliferation of hormone-dependent breast cancer. Apart from free estrogens, which can directly activate the estrogen receptor (ER) of tumor cells, sulfo-conjugated steroids, which maintain high plasma concentrations even after menopause, first
E S M Silva et al.
Theriogenology, 86(7), 1749-1756 (2016-08-09)
The present study evaluated the influence of different regimens of estradiol benzoate (EB) treatments followed by a single dose of long-acting progesterone (LA P4) on plasma estrogen and P4 concentrations in noncyclic mares prepared as embryo recipients. Twenty-one anestrous mares
Christopher A Pearl et al.
Domestic animal endocrinology, 33(4), 451-459 (2006-10-13)
The steroid hormone regulation of the epididymis in a high estrogen producing animal like the boar is not currently understood. To test the hypothesis that the boar epididymis is an estrogen and androgen responsive tissue, the presence of estrogen and
L M M C Sousa et al.
Placenta, 33(10), 788-794 (2012-07-31)
Our objectives were to investigate the possible role of VEGFA in bovine placenta steroid synthesis and to determine whether cloned derived placental cells present similar responses as non-cloned ones. Placental cells from cloned (term) and non-cloned (days 90, 150, 210
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