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I9140

Sigma-Aldrich

IgG from goat serum

technical grade, ≥80% (SDS-PAGE), buffered aqueous solution

Synonym(s):

Goat IgG

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

conjugate

unconjugated

grade

technical grade

Assay

≥80% (SDS-PAGE)

form

buffered aqueous solution

technique(s)

ChIP: suitable
immunohistochemistry: suitable

shipped in

dry ice

storage temp.

−20°C

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General description

Goat IgG is a glycoprotein antibody that is fractionated from pooled normal goat serum. In immunoelectrophoresis, goat IgG yields a single major arc of precipitation in the γ region against anti-goat IgG and anti-goat whole serum. Minor γ arcs may also be observed against anti-goat whole serum.
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
Goat IgG is purified from normal goat serum by fractionation.

Application

In immunohistochemical applications, IgG from goat serum can be used as a blocking agent (500 μg/ml in paraformaldehyde-fixed mouse uterus sections) or as a negative control (1:56000 in pig cecal tissue).
Technical grade IgG may be used as an economical alternative to the reagent grade immunoglobulins, in applications where high purity is not required. Goat IgG was used as negative control antibody in immunohistochemical staining of cecal tissue of pigs at a dilution of 1:56000. Goat IgG was used in immunohistochemistry of rat brain sections at a concentration of 2 μg/ml. The antibody was also used in chromatin immunoprecipitation and as control in infection inhibition assay.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.2 containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Malene M Nørgaard et al.
The Southeast Asian journal of tropical medicine and public health, 36(6), 1394-1398 (2006-04-14)
The pig has been proposed as a model for human schistosomiasis japonica and the use of this animal model is increasing. The inflammatory response to schistosome infection in the liver and intestine of the pig shows morphological differences, and only
Kanin Salao et al.
Parasite immunology, 41(1), e12603-e12603 (2018-11-19)
Liver fluke infection caused by Opisthorchis viverrini induces several hepatobiliary conditions including advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA), but >25% of the infected population develops APF and 1% develop CCA. The innate immune response is the first line of
R Froehlich et al.
Placenta, 33(3), 195-201 (2012-01-14)
The concept of a network within the family of adhesion/growth regulatory galectins implies distinct spatio-temporal expression profiles. To test this assumption immunohistochemically for bovine placenta, placentomal (P) and interplacentomal tissues (IP) were collected at a slaughterhouse from the three stages
Nicole Jungwirth et al.
Journal of molecular neuroscience : MN, 65(1), 60-73 (2018-05-01)
Mesenchymal stem cells (MSCs) are regarded as an immune privileged cell type with numerous regeneration-promoting effects. The in vivo behavior of MSC and underlying mechanisms leading to their regenerative effects are largely unknown. The aims of this study were to
Michael Curley et al.
Scientific reports, 9(1), 15037-15037 (2019-10-23)
Exogenous androgen replacement is used to treat symptoms associated with low testosterone in males. However, adverse cardiovascular risk and negative fertility impacts impel development of alternative approaches to restore/maintain Leydig cell (LC) androgen production. Stem Leydig cell (SLC) transplantation shows

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