P4743
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Bcl-2 Binding Component 3, Anti-p53 Upregulated Modulator of Apoptosis
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~23 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
microarray: suitable
western blot: 2-4 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BBC3(27113)
Related Categories
General description
p53 upregulated modulator of apoptosis (PUMA) protein is a member of the B-cell lymphoma 2 (BCL2) family. It is a pro-apoptotic BCL-2 homology 3 (BH3)-only protein and has a small BH3 domain. The PUMA gene is mapped on the human chromosome at 19q13.32.
Immunogen
synthetic peptide corresponding to amino acids 2 to 16 of human PUMA-α.
Application
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit has been used in western blotting and immunoprecipitation.
Biochem/physiol Actions
p53 upregulated modulator of apoptosis (PUMA) acts as a determinant of the levels of germ cells during ovarian development. It promotes apoptosis in various cellular stress insults. Deletion of the PUMA gene is observed in several kinds of human cancers.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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C Li et al.
Cancer gene therapy, 23(9), 295-302 (2016-08-06)
Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck and is associated with a high rate of lymph node metastasis. The initial step in the metastasis and transition of tumors is epithelial-mesenchymal transition (EMT)-induced
Min Li et al.
Pharmaceuticals (Basel, Switzerland), 16(1) (2023-01-22)
Colorectal cancer is one of the most common malignancies, and the topoisomerase inhibitor irinotecan (CPT-11)-based chemotherapeutic regimen is currently the first-line treatment with impressive therapeutic efficacy. However, irinotecan has several clinically significant side effects, including diarrhea, which limit its clinical
Michelle Myers et al.
Reproduction (Cambridge, England), 148(2), 211-219 (2014-05-27)
The number of primordial follicles initially established within the ovary is influenced by the extent of germ cell death during foetal ovarian development, but the mechanisms that mediate this death have not been fully uncovered. In this study, we identified
Karen S Yee et al.
Apoptosis : an international journal on programmed cell death, 13(1), 87-95 (2007-10-31)
The BH3-only protein PUMA plays an important role in the activation of apoptosis in response to p53. In different studies, PUMA has been described to function by either directly activating the pro-apoptotic proteins Bax and Bak, or by neutralizing anti-apoptotic
Fumin Chang et al.
Physiological reports, 11(22), e15884-e15884 (2023-11-27)
Cooling causes cutaneous dilatation to restrain cold-induced constriction and prevent tissue injury. Cooling increases communication through myoendothelial gap junctions (MEGJs), thereby increasing endothelium-derived hyperpolarization (EDH)-type dilatation. EDH is initiated by calcium-activated potassium channels (KCa ) activated by endothelial stimuli or
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