PZ0233

PF-06424439

≥98% (HPLC)

• Synonym(s): [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
• Empirical Formula (Hill Notation): C₂₂H₂₆ClN₇O · CH₃SO₃H
• CAS Number: 1469284-79-4
• Molecular Weight: 536.05
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823784

Properties

• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +7 to +11°, c = 1.0 in methanol
• color: white to light brown
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O
• InChI: 1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1
• InChI key: ZSTFDNQQOJUJFL-XFULWGLBSA-N

Description

Application

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:

• to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
• to study its effects on HeLa cells
• to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable