R8526
RO-52 (SSA) human
recombinant, expressed in E. coli, liquid
Synonym(s):
Anti-RO-52 antibody
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
mol wt
52 kDa by SDS-PAGE
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... TRIM21(6737)
General description
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
Application
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
Biochem/physiol Actions
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
Physical form
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The Sjogren?s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A, et al.
Journal of Immunology, 176(10), 6277-6285 (2006)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
Anti-ro52 antibodies and interstitial lung disease in connective tissue diseases excluding scleroderma
Ferreira J, et al.
ISRN rheumatology, 2012, 415-421 (2012)
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
Pan JA, et al.
Molecular Cell, 61(5), 720-733 (2016)
Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD 21-/low B Cells From Patients With Sjogren's Syndrome
Glauzy S, et al.
Arthritis and Rheumatism, 70(2), 298-307 (2018)
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