SAB3500420

Anti-RIPK1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-RIP, Anti-RIP1, Anti-Receptor-interacting serine/threonine-protein kinase 1
• MDL number: MFCD01633826
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, rat, mouse
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_003795
• UniProt accession no.: Q13546
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RIPK1(8737)

Description

General description

Receptor interacting serine/threonine kinase 1 (RIPK1) gene is located at 6p25.2 on the human chromosome. It belongs to the RIPK family. RIPK1 is a necroptosis regulatory protein. It is made up of N-terminal kinase domain, a RIP homotypic interaction motif and its C-terminal contains the death domain.

Immunogen

RIPK1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.

Application

Anti-RIPK1 antibody produced in rabbit has been used in:

• western blotting
• immunocytochemistry
• immunofluorescence

Biochem/physiol Actions

Receptor interacting serine/threonine kinase 1 (RIPK1) is involved in inflammatory signaling and prosurvival. It is also involved in regulating the caspase-8-mediated apoptosis. RIPK1 plays a role in activating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein (MAP) kinases. Mutations in this gene is associated with impaired innate and adaptive immunity. It also leads to very early onset inflammatory bowel diseases (VEO-IBDs).

Receptor interacting serine/threonine kinase 1 (RIPK1) modulates cell survival and death. It also has a role in inflammation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500420.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable