SMB00802

Bavachin

from Psoralea coryfolia, ≥97% (HPLC)

• Synonym(s): (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 4′,7-Dihydroxy 6-(3-methyl 2-butenyl)flavanone, Corylifolin
• Empirical Formula (Hill Notation): C₂₀H₂₀O₄
• CAS Number: 19879-32-4
• Molecular Weight: 324.37
• MDL number: MFCD11617359
• UNSPSC Code: 12352205
• NACRES: NA.28

Properties

• Assay: ≥97% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• InChI: 1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3
• InChI key: OAUREGNZECGNQS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Bavachin is a flavonoid isolated from seeds of Psoralea corylifolia. It is a phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively), stimulates osteoblast proliferation and differentiation, and prevents bone loss following ovariectomy in rats.

Bavachin is an inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT). The IC50 value of bavachin was reported to be 86.0 μM in ACAT assay system using rat liver microsome.

Bavachin is also reported to increase insulin-induced glucose uptake by differentiated adipocytes and myoblasts.

Physical properties

Bavachin is soluble in DMSO at 30 mg/mL. Bavachin is not water soluble.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable