SML0121

BTZO-1

≥98% (HPLC)

• Synonym(s): 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one
• Empirical Formula (Hill Notation): C₁₃H₈N₂OS
• CAS Number: 99420-15-2
• Molecular Weight: 240.28
• MDL number: MFCD19690951
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825172
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥7 mg/mL
• originator: Takeda
• storage temp.: 2-8°C
• SMILES string: O=C1N=C(Sc2ccccc12)c3ccccn3
• InChI: 1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H
• InChI key: GBAKVEWPYUIGHN-UHFFFAOYSA-N

Description

Application

BTZO-1 may be used in ARE-mediated gene expression studies.

Biochem/physiol Actions

BTZO-1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable