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SML3181

Sigma-Aldrich

7,8-Dimethoxyperphenazine

≥98% (HPLC)

Synonym(s):

2-(4-(3-((3-chlorophenyl)(3,4-dimethoxyphenyl)amino)propyl)piperazin-1-yl)ethan-1-ol, 4-[3-[8-Chloro-2,3-dimethoxy-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol

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About This Item

Empirical Formula (Hill Notation):
C23H30ClN3O3S
Molecular Weight:
464.02
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=C2C(N(CCCN3CCN(CCO)CC3)C(C=C(C(OC)=C4)OC)=C4S2)=C1

Biochem/physiol Actions

7,8-Dimethoxyperphenazine is a cell penetrant inhibitor of UHM (U2AF homology motif) -ULM (U2AF ligand motif) interactions that interacts with the tryptophan binding pocket of different UHM domains including SPF45, PUF60 and U2AF. 7,8-Dimethoxyperphenazine inhibits early spliceosome assembly on pre-mRNA substrates in vitro.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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