U0881

Uric acid

BioXtra, ≥99% (HPLC)

• Synonym(s): 2,6,8-Trihydroxypurine
• Empirical Formula (Hill Notation): C₅H₄N₄O₃
• CAS Number: 69-93-2
• Molecular Weight: 168.11
• Beilstein: 156158
• EC Number: 200-720-7
• MDL number: MFCD00005712
• UNSPSC Code: 12352005
• PubChem Substance ID: 24900620
• NACRES: NA.55

Properties

• biological source: animal (seabird feces (guano))
• product line: BioXtra
• Assay: ≥99% (HPLC)
• form: powder
• impurities: ≤0.005% Phosphorus (P)
• ign. residue: ≤0.1%
• mp: >300 °C (lit.)
• solubility: 1 M NaOH: soluble 50 mg/mL, clear, faintly yellow
• cation traces: Al: ≤0.005%; Ca: ≤0.01%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.05%; Mg: ≤0.001%; NH₄⁺: ≤0.05%; Na: ≤0.1%; Pb: ≤0.001%; Zn: ≤0.0005%
• SMILES string: O=C1NC(=O)C2=C(N1)NC(=O)N2
• InChI: 1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
• InChI key: LEHOTFFKMJEONL-UHFFFAOYSA-N

Description

General description

Uric acid is the terminal product of purine degradation in humans. It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin. In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite. High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.

Application

Uric acid has been used:

• to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression
• as a reductant to test its protective potential against met-myoglobin formation
• to prepare MSU to study its use as specific ligand of Clec12a.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves