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535311

Sigma-Aldrich

Poly(N-isopropylacrylamide)

Mn ~40,000

Synonym(s):

NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
CH3(C6H11NO)nCH3
CAS Number:
25189-55-3
MDL number:
MFCD00284282
UNSPSC Code:
12162002
PubChem Substance ID:
24877546
NACRES:
NA.23

mol wt

Mn 20,000-60,000
Mn ~40,000

Quality Level

100

mp

96 °C

SMILES string

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)

InChI key

WDFKEEALECCKTJ-UHFFFAOYSA-N

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Related Categories

Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Physical form

Thermosensitive polymer, hydrogel

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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MKCV7874
MKCR8778
MKCR4152
MKCM8563
MKCM8561

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Matteo D'Este et al.
Carbohydrate polymers, 90(3), 1378-1385 (2012-09-04)
An efficient and scale-up ready single-step synthesis for the conjugation of thermoresponsive polymers to hyaluronic acid (HA) was established. Jeffamines(®) (JFM) and poly(N-isopropylacrylamide) (PNIPAM) were grafted to HA via direct amidation mediated by 1,1'-carbonyldiimidazole activation. The temperature-induced gelation of the
Hydrophobic interaction-mediated capture and release of cancer cells on thermoresponsive nanostructured surfaces.
Hongliang Liu et al.
Advanced materials (Deerfield Beach, Fla.), 25(6), 922-927 (2012-11-20)
Tatiya Trongsatitkul et al.
Colloids and surfaces. B, Biointerfaces, 103, 244-252 (2012-12-04)
The effect of PEGylation on the thermal response and protein adsorption resistance of crosslinked PNIPAm microgels was investigated. It was found that the presence of PEG, its molecular weight (M(n) 300 and 1100 g/mol) and its concentration (10, 20, and
Maria E Nash et al.
Stem cell reviews, 9(2), 148-157 (2013-01-29)
The facile regeneration of undifferentiated human mesenchymal stem cells (hMSCs) from thermoresponsive surfaces facilitates the collection of stem cells avoiding the use of animal derived cell detachment agents commonly used in cell culture. This communication proposes a procedure to fabricate
A C C Rotzetter et al.
Advanced materials (Deerfield Beach, Fla.), 24(39), 5352-5356 (2012-08-31)
Buildings can be effectively cooled by a bioinspired sweating-like action based on thermoresponsive hydrogels (PNIPAM), which press out their stored water when exceeding the lower critical solution temperature. The surface temperature is reduced by 15 °C compared to that of
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