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F7503

Sigma-Aldrich

Formamide

ReagentPlus®, ≥99.0% (GC)

Synonym(s):

Amide C1, Formic amide

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About This Item

Linear Formula:
HCONH2
CAS Number:
75-12-7
Molecular Weight:
45.04
Beilstein:
505995
EC Number:
200-842-0
MDL number:
MFCD00007941
UNSPSC Code:
12352111
PubChem Substance ID:
329799765
NACRES:
NA.21
Assay:
≥99.0% (GC)
technique(s):
hybridization: suitable
bp:
210 °C (lit.)
vapor pressure:
0.08 mmHg ( 20 °C)
30 mmHg ( 129 °C)

vapor density

1.55 (vs air)

Quality Level

100

vapor pressure

0.08 mmHg ( 20 °C)
30 mmHg ( 129 °C)

product line

ReagentPlus®

Assay

≥99.0% (GC)

form

liquid

autoignition temp.

932 °F

expl. lim.

2.7-19 %

technique(s)

hybridization: suitable

refractive index

n20/D 1.447 (lit.)

pH

4-10 (20 °C, 200 g/L)

bp

210 °C (lit.)

mp

2-3 °C (lit.)

density

1.134 g/mL at 25 °C (lit.)

SMILES string

NC=O

InChI

1S/CH3NO/c2-1-3/h1H,(H2,2,3)

InChI key

ZHNUHDYFZUAESO-UHFFFAOYSA-N

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General description

Formamide is a polar solvent mainly used for resins and plasticizers. It can be prepared by direct synthesis from carbon monoxide and ammonia.

Application

Formamide can be used as a solvent:
  • To synthesize tetrakis(trialkylsilyl) diphosphate by reacting disodium dihydrogen diphosphate with trialkyl chlorosilane.
  • In Cu/C catalyzed cycloaddition between azides and terminal alkynes to synthesize triazoles.
Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360D,H373

Hazard Classifications

Carc. 2 - Repr. 1B - STOT RE 2 Oral

Target Organs

Blood

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

305.6 °F

Flash Point(C)

152 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS4136
SHBR8951
SHBR4748
SHBS2391
WXBF4327V

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The crystal structure of formamide.
Ladell J and Post B.
Acta Crystallographica, 7(8-9), 559-564 (1954)
Microwave spectrum, structure, dipole moment, and quadrupole coupling constants of formamide.
Kurland RJ and Wilson Jr EB.
J. Chem. Phys. , 27(2), 585-590 (1957)
The formamide method for the extraction of polysaccharides from haemolytic streptococci.
Fuller AT.
British Journal of Experimental Pathology, 19(2), 130-130 (1938)
The dynamics of liquid formamide, N-methylformamide, N,N-dimethylformamide, and N,N-dimethylacetamide. A dielectric relaxation study.
Barthel J, et al.
Journal of Molecular Liquids, 98, 51-69 (2002)
Penelope A Bryant et al.
PloS one, 6(5), e19556-e19556 (2011-06-10)
A central issue in the design of microarray-based analysis of global gene expression is that variability resulting from experimental processes may obscure changes resulting from the effect being investigated. This study quantified the variability in gene expression at each level
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