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A9810

Sigma-Aldrich

Amyloid β Protein Fragment 1-42

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About This Item

Empirical Formula (Hill Notation):
C203H311N55O60S
CAS Number:
107761-42-2
Molecular Weight:
4514.04
MDL number:
MFCD00163049
UNSPSC Code:
12352202
NACRES:
NA.32

Assay

≥95% (HPLC)

Quality Level

200

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(

InChI

1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112

InChI key

DZHSAHHDTRWUTF-SIQRNXPUSA-N

Gene Information

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

General description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Application

Amyloid β Protein Fragment 1-42 has been used:
  • for the preparation of Aβ 1-42 oligomer
  • for western blot analysis
  • for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
  • to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
  • to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions

Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.
The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000388520
0000387190
0000368432
0000336675
0000331858

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Plasma Amyloid-beta(Abeta 42) Correlates with Cerebrospinal Fluid Abeta 42 in Alzheimer?s Disease
Teunissen CE, et al.
Journal of Alzheimer'S Disease, 1-7 (2018)
The role of Abeta circRNA in Alzheimer? s disease: alternative mechanism of Abeta biogenesis from Abeta circRNA translation
Mo D, et al.
bioRxiv, 260968-260968 (2018)
Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor alpha and the Activity of gamma-secretase in a beta-amyloid Protein-dependent Mechanism in APP/PS1 Transgenic Mice
Yu X, et al.
Frontiers in Molecular Neuroscience, 11 (2018)
beta-amyloid expression in age-related cataract lens epithelia and the effect of beta-amyloid on oxidative damage in human lens epithelial cells
Xu J, et al.
Molecular Vision, 23, 1015-1015 (2017)
Kyunghee Byun et al.
PloS one, 7(5), e37917-e37917 (2012-06-05)
Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we demonstrate that AGE-albumin, the most abundant AGE product in human
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