14024AST

Astec^® CHIROBIOTIC^® TAG Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

• UNSPSC Code: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Properties

• Product Name: Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
• material: stainless steel column
• Quality Level: 100
• Agency: suitable for USP L63
• description: HPLC column
• product line: Astec^®
• packaging: pkg of 1 ea
• manufacturer/tradename: Astec^®
• parameter: 0-45 °C temperature; 241 bar pressure (3500 psi)
• technique(s): HPLC: suitable; LC/MS: suitable
• L × I.D.: 25 cm × 4.6 mm
• matrix: High-purity silica gel particle platform; fully porous particle
• matrix active group: teicoplanin aglycone phase
• particle size: 5 μm
• pore size: 100 Å
• operating pH range: 3.0-6.8
• separation technique: chiral

Description

General description

The removal of three carbohydrate moieties gives CHIROBIOTIC^® TAG complementary selectivity to CHIROBIOTIC^® T. Resolution is enhanced toward many of the amino acids, α, β, γ and cyclic, and especially sulfur-containing methionine, histidine and cysteine. A number of neutral molecules like the oxazolidinones, hydantoins and diazepines have shown enhanced resolution and, more remarkably, in the single solvents like methanol, ethanol and acetonitrile. Some acidic molecules have also shown increased selectivity.

• Bonded phase: Teicoplanin aglycone
• Operating pH range: 3.0 - 6.8
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å

Application

• High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This study emphasizes the effectiveness of the Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column in the enantioseparation of complex cyclic amino acids. The methodology detailed provides profound insights into the chirality aspects of biochemical molecules, which is crucial for the synthesis of novel pharmaceutical agents and the study of biochemical pathways. This research supports analytical chemists in academia focused on developing chiral analytical methods and advancing chemical synthesis (Berkecz et al., 2009).

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable