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810193C

Avanti

16:0-12:0 NBD PS

Avanti Research™ - A Croda Brand 810193C

Synonym(s):

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoserine (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C40H71N6O13P
CAS Number:
384833-07-2
Molecular Weight:
875.00
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810193C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810193C

concentration

1 mg/mL (810193C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphoserine (PS) is present in the intracellular membranes and grey matter, and isenriched in the cytosolic leaflet of plasma membrane. NBD PS is a fluorescently labelled lipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the headgroup of PS.

Application

16:0-06:0 NBD PS or 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt) may be used in the liposome preparation for in vitro assay of the phosphatidylethanolamine (PE) production by determining the phosphatidylserine decarboxylase 1 (Psd1p) activity.

Biochem/physiol Actions

Phosphatidylserine (PS) regulates numerous enzymes and structural components maintains the nerve cell membrane and myelin sheath.

Packaging

5 mL Amber Glass Screw Cap Vial (810193C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yasushi Tamura et al.
The Journal of biological chemistry, 287(52), 43961-43971 (2012-11-06)
Phosphatidylethanolamine (PE) plays important roles for the structure and function of mitochondria and other intracellular organelles. In yeast, the majority of PE is produced from phosphatidylserine (PS) by a mitochondrion-located PS decarboxylase, Psd1p. Because PS is synthesized in the endoplasmic
Ouma Onguka et al.
The Journal of biological chemistry, 290(20), 12744-12752 (2015-04-02)
Phosphatidylethanolamine (PE) is a major cellular phospholipid that can be made by four separate pathways, one of which resides in the mitochondrion. The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). The pool of PE produced by Psd1p
Jean E Vance et al.
Progress in lipid research, 44(4), 207-234 (2005-06-28)
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss
Michael J Glade et al.
Nutrition (Burbank, Los Angeles County, Calif.), 31(6), 781-786 (2015-05-03)
The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function. A scientific literature search was conducted on MEDLINE for relevant articles regarding
Soumi Mukherjee et al.
Chemistry and physics of lipids, 127(1), 91-101 (2004-01-07)
Lipids that are labeled with the NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) group are widely used as fluorescent analogues of native lipids in biological and model membranes to monitor a variety of processes. NBD-labeled lipids have previously been used to monitor the organization and
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