Skip to Content
Merck
All Photos(1)

Key Documents

524624

Sigma-Aldrich

Phosphatase Inhibitor Cocktail I

liquid, for the inhibition of alkaline phosphatases and serine/threonine protein phosphatases

Synonym(s):

Phosphatase inhibitor

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352200
NACRES:
NA.28

product name

Phosphatase Inhibitor Cocktail Set I, Phosphatase Inhibitor Cocktail Set I contains three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A.

Quality Level

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

ambient

storage temp.

−20°C

General description

A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product is provided as a set of five 1 ml vials. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components: Bromotetramisole oxalate (2.5 mM), Cantharidin (Cat. No. 210155; 500 µM), and Microcystin-LR (Cat. No. 475815; 500 nM).
A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product is provided as a set of five 1 ml vials. May be used with cell lysates and tissue extracts, including samples containing detergents. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components:

Biochem/physiol Actions

Cell permeable: no
Primary Target
Alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A
Product does not compete with ATP.
Reversible: no

Physical form

In DMSO.

Reconstitution

For long-term storage, aliquot and freeze (-20°C). Dilute 1:100 just prior to use.

Legal Information

Not available for sale outside of the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point(C)

87 °C - closed cup - (Dimethylsulfoxide)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Rama K Mishra et al.
Chemical biology & drug design, 94(4), 1813-1823 (2019-07-02)
Mnk kinases (Mnk1 and 2) are downstream effectors of Map kinase pathways and regulate phosphorylation of eukaryotic initiation factor 4E. Engagement of the Mnk pathway is critical in acute myeloid leukemia (AML) leukemogenesis and Mnk inhibitors have potent antileukemic properties
An Phu Tran Nguyen et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(29), 17296-17307 (2020-07-08)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson's disease (PD). LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities. While PD-linked LRRK2
Agnes S Zybura et al.
The Journal of biological chemistry, 295(33), 11845-11865 (2020-07-03)
Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons
Hajime Maeda et al.
Respiratory research, 23(1), 340-340 (2022-12-11)
Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. We and others have shown that hyperoxia causes senescence in cultured lung epithelial cells and fibroblasts.
Ashley Batra et al.
Molecular and cellular biochemistry, 476(3), 1337-1349 (2021-01-04)
It is known that there is an age-related progression in diastolic dysfunction, especially prevalent in postmenopausal women, who develop heart failure with preserved ejection fraction (HFpEF, EF > 50%). Mechanisms and therapies are poorly understood, but there are strong correlations between obesity

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service