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10416

Sigma-Aldrich

8-Anilino-1-naphthalenesulfonic acid ammonium salt

technical, ≥90% (NT)

Synonym(s):

1,8-ANS NH4, ANSA, Ammonium 8-anilino-1-naphthalenesulfonate, N-Phenyl peri acid

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About This Item

Linear Formula:
C16H13NO3S · NH3
CAS Number:
28836-03-5
Molecular Weight:
316.37
Beilstein:
3581235
EC Number:
249-265-6
MDL number:
MFCD00012560
UNSPSC Code:
12352106
PubChem Substance ID:
329749052
NACRES:
NA.32

grade

technical

Quality Level

200

Assay

≥90% (NT)

form

powder

color

, Green to Dark Green and Grey to Dark Grey and Green-Grey

solubility

NaOH: 1 N
H2O: soluble
methanol: soluble

fluorescence

λex 388 nm; λem 470 nm in 0.1 M Tris, 0.2 M KCl, pH 9.0, BSA

SMILES string

N.OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12

InChI

1S/C16H13NO3S.H3N/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13;/h1-11,17H,(H,18,19,20);1H3

InChI key

IPBNQYLKHUNLQE-UHFFFAOYSA-N

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Application

ANS forms an inclusion complex with cyclodextrin. Such model systems are useful to mimic biological recognition and can be studied by measuring the change in fluorescence of free-ANS to complexed-ANS. When ANS enters the hydrophobic core of cyclodestrin, it′s fluorescence increases . Utilized in the reagent phase of a sodium-selective fiber-optic sensor. The reagent phase also contains a copper(II) polyelectrolyte, which binds to ANSA in the absence of sodium and quenches the fluorescence. In the presence of sodium, ANSA forms a cationic complex creating ion-pairs, causing it to fluoresce . ANS is often incorporated into di-block polymers and can be released by changes in the local environment (i.e., temperature, pH, etc.) . ANS is commonly used as a fluorescence probe to investigate molecular assemblies of surfactants and amphiphilic polymers because a blue shift of the emission maximum indicates the fluorophore is located in less polar media . Fluorescent probe for protein studies using methodologies such as steady-state and dynamic fluorescence measurements .

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF2432V
WXBF3713V
WXBF4162V
BCCK6146
BCCH0786

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Irina M Kuznetsova et al.
PloS one, 7(7), e40845-e40845 (2012-07-26)
In this work we return to the problem of the determination of ligand-receptor binding stoichiometry and binding constants. In many cases the ligand is a fluorescent dye which has low fluorescence quantum yield in free state but forms highly fluorescent
L V Belovolova et al.
Biofizika, 56(2), 197-204 (2011-05-06)
For investigation of influence of reactive oxygen species on biological systems the peculiarities of light scattering and fluorescence spectra of aqueous solutions in the presence of photoactive additions of acetone (5 x 10(-4) - 30) and anionic probe ANS (5
Sergio B Kaufman et al.
The journal of physical chemistry. B, 116(10), 3421-3429 (2012-01-31)
Folding and structural stability are key factors for the proper biological function of proteins. Na(+),K(+)-ATPase is an integral membrane protein involved in the active transport of Na(+) and K(+) across the plasma membrane. In this work we characterized the effects
Andrea Pica et al.
Biochimica et biophysica acta, 1824(4), 571-577 (2012-02-11)
γ-glutamyltranspeptidases (γ-GTs) are ubiquitous enzymes that catalyze the hydrolysis of γ-glutamyl bonds in glutathione and glutamine and the transfer of the released γ-glutamyl group to amino acids or short peptides. These enzymes are generally synthesized as precursor proteins, which undergo
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