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S2000000

Sulfamerazine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide, N1-(4-Methylpyrimidin-2-yl)sulfanilamide

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About This Item

Empirical Formula (Hill Notation):
C11H12N4O2S
CAS Number:
Molecular Weight:
264.30
Beilstein:
249133
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

sulfamerazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

InChI key

QPPBRPIAZZHUNT-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulfamerazine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Pól Macfhionnghaile et al.
Journal of pharmaceutical sciences, 103(6), 1766-1778 (2014-04-24)
The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete amorphization of both polymorphs. Milling at room temperature gave
Zhe Meng et al.
Food chemistry, 174, 597-605 (2014-12-23)
A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)
Hao Lou et al.
Pharmaceutical development and technology, 19(5), 548-555 (2013-06-15)
The purpose of this study is to evaluate the influence of sodium iodide, sodium chloride and sodium sulfate on the formation efficiency of sulfamerazine nanocrystals by wet ball milling. Sulfamerazine was milled using zirconium oxide beads in a solution containing
Qing Wang et al.
Analytica chimica acta, 854, 191-201 (2014-12-07)
A hydrophilic stationary phase (SP) was prepared through grafting N-methylene phosphonic acid chitosan on magnesia-zirconia particles (P-CTS-MgO-ZrO2) via Lewis acid-base interaction. The resulting material was characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscope and nitrogen adsorption analysis.
Qing Wang et al.
Talanta, 129, 438-447 (2014-08-17)
In the current study, zirconia (ZrO2) and its composite, magnesia-zirconia (MgO-ZrO2), were prepared as the hydrophilic interaction chromatographic (HILIC) stationary phases (SPs). Different experimental variables including water content, pH and buffer concentration in the mobile phase (MP) as well as

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