Y0000468
Brotizolam
European Pharmacopoeia (EP) Reference Standard
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About This Item
Empirical Formula (Hill Notation):
C15H10BrClN4S
CAS Number:
Molecular Weight:
393.69
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
pharmaceutical primary standard
API family
brotizolam
manufacturer/tradename
EDQM
drug control
psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
InChI key
UMSGKTJDUHERQW-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Brotizolam EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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T Osanai et al.
British journal of clinical pharmacology, 58(5), 476-481 (2004-11-04)
To assess the effect of itraconazole, a potent inhibitor of cytochrome P450 (CYP)3A4, on the single oral dose pharmacokinetics and pharmacodynamics of brotizolam. In this randomized, double-blind, cross-over trial 10 healthy male subjects received either itraconazole 200 mg or matched
Tomoki Nishiyama et al.
Journal of anesthesia, 21(1), 7-12 (2007-02-08)
The purpose of this study was to evaluate the effects of quazepam, a long-acting hypnotic, as a preoperative night medication in comparison with brotizolam, a shortacting hypnotic. Two hundred patients (aged 30 to 70 years) admitted for elective general anesthesia
Takaki Tokairin et al.
British journal of clinical pharmacology, 60(2), 172-175 (2005-07-27)
To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. Fourteen healthy male volunteers received erythromycin 1200 mg day(-1) or placebo for 7 days in a double-blind randomized crossover manner. On the
Shlomit Jacobson-Pick et al.
The international journal of neuropsychopharmacology, 11(7), 891-903 (2008-03-28)
Profound evidence indicates that GABAA receptors are important in the control of physiological response to stress and anxiety. The alpha subunit type composition contributes significantly to the functional characterization of the GABAA receptors. The alpha2, alpha3, alpha5 subunits are predominately
Paradoxical reactions to hypnotic agents in adolescents with free-running disorder.
Masaru Echizenya et al.
Psychiatry and clinical neurosciences, 63(3), 428-428 (2009-07-02)
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