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131M-9

Sigma-Aldrich

CD31 (JC70) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

JC70, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (131M-94)
vial of 0.5 mL concentrate (131M-95)
bottle of 1.0 mL predilute (131M-97)
vial of 1.0 mL concentrate (131M-96)
bottle of 7.0 mL predilute (131M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG1κ

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... PECAM1(5175)

General description

CD31, or platelet/endothelial cell adhesion molecule-1 (PECAM-1), is a vascular cell adhesionand signaling molecule that plays a role in maintaining the vascular permeability barrierat endothelial cell junctions. Immunohistochemical detection of CD31 shows cytoplasmicand membranous expression in non-neoplastic and neoplastic vascular endothelial cells,including neoplasms of vascular origin such as hemangiomas and angiosarcomas.

Linkage

CD31 Positive Control Slides, Product No. 131S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CD31: An Immunospecific Marker for Endothelial Differentiation in Human Neoplasms
DeYoung BR, et al.
Appl. Immunohistochem., 1, 97-100 (1993)
J U Alles et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 34(2), 209-214 (1986-02-01)
A new monoclonal antibody (moab BW 200) of IgG3 kappa-isotype was generated which recognizes an epitope located on an antigen molecule restricted to human neoplastic and non-neoplastic endothelial cells. The molecular weight of the antigen was determined using immunoprecipitation analysis
Xiu-Lian Xu et al.
The American Journal of dermatopathology, 32(8), 837-840 (2010-10-01)
Microvenular hemangioma (MVH) is an uncommon benign vascular neoplasm that usually occurs as a solitary asymptomatic red or purple papule, nodule, or plaque with a predilection for the upper extremities. Patients with more than 1 lesion, that is, multiple MVHs
Malak Abedalthagafi et al.
Annals of diagnostic pathology, 14(1), 15-22 (2010-02-04)
Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis. Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its
R L Attanoos et al.
Thorax, 55(10), 860-863 (2000-09-19)
Three cases of diffuse malignant vascular tumours of the pleura are described which mimicked malignant mesothelioma clinically and pathologically (so called "pseudomesothelioma"). All had occupational histories of exposure to asbestos. The relationship of these tumours to mesothelioma and asbestos exposure
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