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60142

Sigma-Aldrich

Potassium chloride solution

BioUltra, for molecular biology, ~1 M in H2O

Synonym(s):

KCl, potassium chloride

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About This Item

Linear Formula:
KCl
CAS Number:
Molecular Weight:
74.55
Beilstein:
1711999
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.26

grade

for molecular biology

product line

BioUltra

concentration

~1 M in H2O

impurities

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected
≤0.001% total nitrogen (N)

pH

5.0-8.0 (25 °C, 1 M in H2O)

density

1.04 g/mL at 20 °C

anion traces

sulfate (SO42-): ≤10 mg/kg

cation traces

Al: ≤1 mg/kg
Ba: ≤1 mg/kg
Bi: ≤1 mg/kg
Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Mo: ≤1 mg/kg
Na: ≤20 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01

SMILES string

[Cl-].[K+]

InChI

1S/ClH.K/h1H;/q;+1/p-1

InChI key

WCUXLLCKKVVCTQ-UHFFFAOYSA-M

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General description

Potassium is an intracellular cation with just 2% of total body K+ inhabiting the extracellular fluid. The distribution of K+ between the intracellular and extracellular space is analyzed by the action of several transport pathways like Na+-K+-ATPase, the Na+-K+-2Cl-cotransporter NKCC1, the four KCCs, and a plethora of K+ channels. Also, skeletal muscle comprises almost 75% of total body potassium and elicits considerable influence on extracellular K+. Potassium chloride is consumed orally to prevent or correct potassium depletion caused by diuretic use or other conditions. It is used as a food supplement and salt substitute.

Application

Potassium chloride solution has been used as a component of:
  • multiple annealing and looping based amplification cycles (MALBAC) lysis buffer to digest proteins for single-cell multiomics sequencing
  • single-cell tagged reverse transcription (STRT) buffer, and STRT-RT buffer for single-cell RNA-sequencing
  • phosphate buffer saline (PBS) to wash transfected cells

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nucleic acids research, 41(10), 5263-5272 (2013-04-13)
Bacterial nucleoid-associated proteins, such as H-NS-like proteins in Enterobacteriaceae, are abundant DNA-binding proteins that function in chromosomal DNA organization and gene transcription regulation. The Mycobacterium tuberculosis Lsr2 protein has been proposed to be the first identified H-NS analogue in Gram-positive
Calista K L Ng et al.
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mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'. The DCPS protein is the scavenger

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