C1172

ML-9

≥99% (TLC), powder

• Synonym(s): 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
• Linear Formula: C₁₅H₁₇N₂O₂SCl · HCl
• CAS Number: 105637-50-1
• Molecular Weight: 361.29
• MDL number: MFCD00065525
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278297
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥99% (TLC)
• form: powder
• color: white
• solubility: ethanol: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N
• Gene Information: human ... SLC2A1(6513) , SLC2A4(6517)

Description

Application

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

Biochem/physiol Actions

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca₂⁺ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves