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E6527

Sigma-Aldrich

Elastin, soluble from bovine neck ligament

salt-free, lyophilized powder

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About This Item

CAS Number:
9007-58-3
EC Number:
232-701-4
MDL number:
MFCD02687372
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

bovine neck ligament

Quality Level

100

form

salt-free, lyophilized powder

technique(s)

UV/Vis spectroscopy: suitable

UniProt accession no.

P04985

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

cow ... ELN(280781)

General description

Water-soluble powder prepared by method of Partrige, et al.

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.

Biochem/physiol Actions

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

Caution

Forms coacervate at pH 5.0 and 37 °C

Suitability

Suitable for determination of elastolytic activity as described by Keller and Mandi.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felix Cleemann et al.
Analytical chemistry, 80(11), 4170-4174 (2008-04-25)
A novel fluorescence polarization assay based on the natural fluorophore epicocconone has been developed. This assay allows the rapid and accurate determination of enzyme kinetic parameters as well as inhibition constants through the measurement of fluorescence anisotropy on the actual
Mervyn J Merrilees et al.
Respiratory research, 9, 41-41 (2008-05-20)
COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of
Elodie Parzy et al.
PloS one, 8(2), e57946-e57946 (2013-03-08)
Magnetic resonance imaging can reveal exquisite anatomical details. However several diseases would benefit from an imaging technique able to specifically detect biochemical alterations. In this context protease activity imaging is one of the most promising areas of research. We designed
O Gutierrez-Navarro et al.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, 1081-1084 (2013-02-01)
Multi-Spectral Fluorescent Lifetime Imaging Microscopy (m-FLIM) is a technique that aims to perform noninvasive in situ clinical diagnosis of several diseases. It measures the endogenous fluorescence of molecules, recording their lifetime decay in different wavelength bands. This signal is a
Yuanming Liu et al.
Physical review letters, 110(16), 168101-168101 (2013-05-18)
Elastin is an intriguing extracellular matrix protein present in all connective tissues of vertebrates, rendering essential elasticity to connective tissues subjected to repeated physiological stresses. Using piezoresponse force microscopy, we show that the polarity of aortic elastin is switchable by
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