GW20025F
Anti-GM-CSF antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CSF, Anti-Colony-stimulating factor, Anti-Granulocyte-Macrophage Colony Stimulating Factor, Anti-MGC131935
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-20025F
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CSF2(1437)
General description
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also termed as CSF-2. It is a glycoprotein that consists of 127 amino acids. This gene is located on human chromosome 5q31.
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF-2, is encoded by the gene mapped to human chromosome 5q31-33. The encoded protein is expressed in a wide variety of immune cell types, including macrophages, mast cells and T cells, mainly in response to immune activation and inflammatory cytokines. In addition, it is also secreted in various non-immune cell types, such as endothelial cells, keratinocytes and fibroblasts, following the appropriate stimuli.
Application
Anti-GM-CSF antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.
Biochem/physiol Actions
GM-CSF (Granulocyte-macrophage colony-stimulating factor) is a pleiotropic cytokine that regulates the growth and differentiation of granulocytes, macrophages, eosinophils and erythrocytes. The gene is present in a cluster along with interleukin-3 (IL-3), IL-4 and IL-5 on chromosome 5.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates binding of eosinophils to vascular cell adhesion molecule-1 and eosinophil migration into tissues. In addition, it is also implicated in maturation of antigen presenting cells. GM-CSF plays an essential role in modulation of surfactant homeostasis and alveolar macrophage innate immune responses in the lung. It also plays a vital role immune-independent tumor progression. Mutation in the gene is associated with the development of atopic asthma.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used in the treatment of neutropenia and leukemia in combination with chemotherapies. It plays a major role in proliferation and differentiation of granulocytes and macrophages from bone marrow progenitor cells. GM-CSF also play a vital role in immune regulation and hematopoiesis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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B H van Leeuwen et al.
Blood, 73(5), 1142-1148 (1989-04-01)
The human genes for the hematopoietic growth factors interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been mapped to 5q23-31. We present in situ hybridization evidence that the human IL-4 gene is located at 5q23.3-31.2, suggesting that the four
K Kaushansky et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(10), 3101-3105 (1986-05-01)
Through the use of long single-sequence oligonucleotide probes, the complete gene for human granulocyte-macrophage colony-stimulating factor (hGM-CSF) has been cloned from a human genomic library. The gene is 2.5 kilobases in length, contains three introns, and is present as a
Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Sabine Hoffjan et al.
American journal of human genetics, 76(4), 696-704 (2005-02-24)
Asthma is a common disease that results from both genetic and environmental risk factors. Children attending day care in the 1st year of life have lower risks for developing asthma, although the mechanism for this "day care" effect is largely
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