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N5536

Sigma-Aldrich

Nefazodone hydrochloride

≥98% (HPLC), solid, selective serotonin reuptake inhibitor

Synonym(s):

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

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About This Item

Empirical Formula (Hill Notation):
C25H32ClN5O2 · HCl
CAS Number:
82752-99-6
Molecular Weight:
506.47
MDL number:
MFCD00935760
UNSPSC Code:
12352200
PubChem Substance ID:
24724551
NACRES:
NA.77

Product Name

Nefazodone hydrochloride, ≥98% (HPLC), solid

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

DMSO: ≥10 mg/mL
H2O: insoluble

originator

Bristol-Myers Squibb

SMILES string

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key

DYCKFEBIOUQECE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

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Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000321806
0000147261
0000247033
0000247032
0000162143

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S C Collins et al.
Diabetologia, 51(9), 1689-1693 (2008-07-16)
Long-term exposure to NEFAs leads to inhibition of glucose-induced insulin secretion. We tested whether the release of somatostatin and glucagon, the two other major islet hormones, is also affected. Mouse pancreatic islets were cultured for 72 h at 4.5 or
Jonathan N Bauman et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1016-1029 (2008-03-12)
In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attempt to understand the differences in toxicological profile. NADPH-supplemented microsomal incubations of nefazodone and glutathione generated conjugates
Ahmed Elkashef et al.
Substance abuse, 29(3), 17-29 (2008-12-02)
Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for
W H Denton et al.
Psychological medicine, 40(3), 415-424 (2009-07-18)
Dyadic discord, while common in depression, has not been specifically evaluated as an outcome predictor in chronic major depressive disorder. This study investigated pretreatment dyadic discord as a predictor of non-remission and its relationship to depressive symptom change during acute
Marc B J Blom et al.
Transcultural psychiatry, 47(3), 473-490 (2010-08-07)
This article presents the results of a large efficacy study comparing different forms of therapy for major depressive disorder (MDD), including interpersonal psychotherapy (IPT) and pharmacotherapy. Patients were randomized to either IPT, IPT in combination with anti-depressant medication, IPT in
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