N9412

6β-Naltrexol hydrate

≥96% (HPLC), powder

• Synonym(s): (5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol hydrate
• Empirical Formula (Hill Notation): C₂₀H₂₅NO₄ · xH₂O
• CAS Number: 1034528-53-4
• Molecular Weight: 343.42 (anhydrous basis)
• MDL number: MFCD08277038
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724560
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥96% (HPLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: white
• solubility: DMSO: ~12 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: [H]O[H].O[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CC6)c45
• InChI: 1S/C20H25NO4.H2O/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,14-15,18,22-24H,1-2,5-10H2;1H2/t14-,15-,18+,19+,20-;/m1./s1
• InChI key: VHGGWFVHXKTOPK-CDHBEYIESA-N

Description

Biochem/physiol Actions

Neutral antagonist of the μ-opioid receptor. A reduction of withdrawal effects associated with neutral μ-opioid receptor antagonists may offer advantages in treating opioid overdose and addiction.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves