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PLA0140

Sigma-Aldrich

Rabbit anti-Phospho KAP-1 (S824) Antibody, Affinity Purified

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Synonym(s):

E3 SUMO-protein ligase TRIM28, KAP-1, KAP1, KRAB [Kruppel-associated box domain]-associated protein 1, KRAB-associated protein 1, KRAB-interacting protein 1, KRIP-1, PPP1R157, RING finger protein 96, RNF96, TF1B, TIF1-beta, TIF1B, Tripartite motif-containing protein 28, nuclear corepressor KAP-1, protein phosphatase 1, regulatory subunit 157, transcriptional intermediary factor 1-beta

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

technique(s)

immunocytochemistry: 1:200-1:1,000
immunofluorescence: 1:200-1:1,000
immunohistochemistry: 1:2000-1:1,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

accession no.

NP_005753.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

phosphorylation (pSer824)

Gene Information

human ... KIFAP3(22920)

Immunogen

Immunogen was a synthetic phosphorylated peptide, which represented a portion of human KRAB-Associated Protein 1 surrounding Serine 824 according to the numbering given in entry NP_005753.1 (GeneID 10155).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lei Shi et al.
Nature communications, 10(1), 2588-2588 (2019-06-15)
The brain is a genomic mosaic shaped by cellular responses to genome damage. Here, we manipulate somatic genome stability by conditional Knl1 deletion from embryonic mouse brain. KNL1 mutations cause microcephaly and KNL1 mediates the spindle assembly checkpoint, a safeguard
Matthias Pfeifer et al.
Journal of immunology (Baltimore, Md. : 1950), 202(12), 3423-3433 (2019-05-16)
Induction of programmed DNA damage and its recognition and repair are fundamental for B cell development. The ssDNA-binding protein SSB1 has been described in human cells as essential for the recognition and repair of DNA damage. To study its relevance
Kasumi Kawamura et al.
Journal of radiation research, 60(3), 281-288 (2019-03-07)
The nucleolus contains multiple copies of ribosomal (r)DNA, which indicate sites of frequent replication stress and suggest the existence of a mechanism to prevent replication stress-related rDNA instability and the possibility that such a mechanism contributes to the whole genomic
Bo-Ruei Chen et al.
The Journal of cell biology, 218(7), 2113-2123 (2019-05-28)
XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent with an isolated defect in NHEJ. Here we show that

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