SAB4300637

Anti-FGFR4 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CD334, Anti-JTK2, Anti-MGC20292, Anti-TKF
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~110 kDa
• species reactivity: human, rat
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (L-T-V-A-L)
• NCBI accession no.: NM_002011.3
• UniProt accession no.: P22455
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FGFR4(2264)

Description

General description

FGFR4 (fibroblast growth factor receptor 4) belongs to FGFR kinase family. In adult tissues, FGFR is expressed in a cell type-specific mode. It is located on chromosome 5q35.

The antibody detects endogenous level of total FGFR4 protein.

Immunogen

Peptide sequence around aa. 45-49 ( L-T-V-A-L), according to the protein NP_002002.3

Biochem/physiol Actions

Aberrations in FGFR4 results in neuroblastoma and altered receptor degradation. It acts as a predictive biomarker in oral and oropharyngeal squamous cell carcinoma. Suppressing FGFR4 may affect the biological characteristics in gastric cancer cells.

Features and Benefits

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Target description

Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable